use a join rather than sub queries in the select clause.
select
u.id,
u.user_login,
u.user_email,
u.user_registered,
sub_level.meta_value as sub_level,
sub_region.meta_value as sub_region
from wp_users u
inner join wp_usermeta sub_level on u.id = sub_level.user_id and sub_level.meta_key = 'wp_capabilities' and sub_level.meta_value like '%s2member_%'
inner join wp_usermeta sub_region on u.id = sub_region.user_id and sub_region.meta_value like '%county%'
Does the region not have an appropriate meta_key value to filter on?